The Simon Wiesenthal Center (SWC) is a Jewish human rights organization established in 1977 by Rabbi Marvin Hier. The center is known for Holocaust research and remembrance, hunting Nazi war criminals, combating anti-Semitism, tolerance education, defending Israel, and its Museum of Tolerance.

The center has close ties to public and private agencies, and regularly meets with elected officials of the United States and foreign governments and with diplomats and heads of state. It is accredited as a non-governmental organization (NGO) at the United Nations, UNESCO, and the Council of Europe.

The center publishes a seasonal magazine, In Motion.

The center is named in honor of Nazi hunter Simon Wiesenthal. Wiesenthal had nothing to do with its operation or activities other than giving its name, but he remained supportive of it. "I have received many honors in my lifetime," Wiesenthal once said, "when I die, these honors will die with me. But the Simon Wiesenthal Center will live on as my legacy."